Lago, Natalia


Universidad o Centro de Investigación: Institut Pasteur Montevideo  

Departamento, unidad o laboratorio: Laboratorio de Neurodegeneración  

Dirección postal: Mataojo 2020  

Código postal: 11400  

País: Uruguay  

Teléfonos de contacto:  

Fax: (598) 2 522 41 85  

Correos electrónicos de contacto:  

  nlago@pasteur.edu.uy 


Linea(s) de investigación

1. Papel de especies modificadas de NGF en dolor inflamatorio
2. Regeneración del Sistema Nervioso Periférico: papel de la proteína BLBP en regeneración específica

Miembros del grupo

Nombre: Federica Cetra E-mail: fedecetra@pasteur.edu.uy  

Nombre: Patricia Solari  

Publicaciones más relevantes

1. Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. Metallothionein-1 2 protect the CNS after a focal brain injury. Exp Neurol 2002; 173:114-128.
2. Giralt M, Penkowa M, Hernández J, Molinero A, Carrasco J, Lago N, Camats J, Campbell I.L, Hidalgo J. Metallothionein-1 2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiol Dis 2002; 9:319-338.
3. Molinero A, Penkowa M, Hernández J, Camats J, Giralt M, Lago N, Carrasco J, Campbell I.L, Hidalgo J. Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. J Neuropathol Exp Neurol 2003; 62(3):315-328.
4. Penkowa M, Giralt M, Lago N, Camats J, Carrasco J, Hernández J, Molinero A, Campbell I.L, Hidalgo J. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol 2003; 181:130-148.
5. Ceballos D, Lago N, Verdú E, Penkowa M, Carrasco J, Navarro X, Palmiter R.D, Hidalgo J. Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol Life Sci 2003; 60:1209-1216.
6. Negredo P, Castro J, Lago N, Navarro X, Avendaño C. Regrowth of severed axons from dorsal root ganglia and spinal motor neurons through a regenerative electrode: a stereological, retrograde tracer, and functional study in the rat. Neuroscience 2004; 128:605-615
7. Uranga A, Lago N, Navarro X, Barniol N. A low noise CMOS amplifier for ENG signals. Proceedings of the IEEE International Symposium on Circuits and Systems 2004; 4:IV-21-IV-24.
8. Lago N, Ceballos D, Rodríguez FJ, Stieglitz T, Navarro X. Long term assessment of axonal regeneration through polyimide regenerative electrodes to interface the peripheral nerve. Biomaterials 2005;26; 2021-2031.
9. Navarro X, Krueger T, Lago N, Micera S, Stieglitz T, Dario P. A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems. J Peripher Nerv Syst 2005; 10;229-258.
10. Lago N and Navarro X. Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve. J Neurotrauma 2006;Feb;23(2):227-40.
11. Ramachandran A, Schuettler M, Lago N, Doerge T, Koch KP, Navarro X, Stieglitz T, Hoffmann KP. Design, in vitro and in vivo assessment of a multi-channel sieve electrode with integrated multiplexer. J Neural Eng 2006; 3:114-124.
12. Lago N, Yoshida K, Koch KP, Navarro X. Assessment of biocompatibility of chronically implanted polyimide and platinum intrafascicular electrodes. IEEE Trans Biomed Eng 2007; 54(2):281-90.
13. Lago N, Udina E, Ramachandran A, Navarro X. Neurobiological assessment of regenerative electrodes for bidireccional interfacing injured peripheral nerves. IEEE Trans Biomed Eng 2007; 54(6):1129-37.
14. Lago N, Rodriguez F, Guzman M, Jaramillo J, Navarro X. Effects of motor and sensory nerve transplants on amount and specificity of sciatic nerve regeneration. J Neurosci Res 2007; 85:2800-2812.
15. Lago N, Navarro X. Evaluation of the long-term regenerative potential in an experimental nerve amputee model. J Peripher Nerv Syst 2007; 12:108-120.
16. Choi C, Carpaneto J, Lago N, Kim J, Dario P, Navarro X, Micera S. Classification of afferent signals recorded with a slingle cuff electrode. Conf Proc IEEE Eng Med Biol Soc. 2007;1:2385-2388.
17. Lago N, Casas C, Muir EM, Rogers R, Navarro X. Effects of Schwann cell transplants in an experimental nerve amputee model. Restor Neurol Neurosci 2009; 27(1):67-78.
18. Lacour SP, FitzGerald JJ, Lago N, Tarte E, McMahon SB, Fawcett J. Long Micro-Channel Electrode Arrays: a novel type of regenerative Peripherals nerve interface. IEEE Trans Biomed Eng 2009; 17: 454-60.
19. Watling CP, Lago N, Benmerah S, FitzGerald JJ, Tarte E, McMahon SB, Lacour SP, Cameron RE. J Neurosci Meth 2010; Feb 2.
20. Fricker FR, Lago N, Balarajah S, Tsantoulas C, Tanna S, Zhu N, Fageiry SK, Jenkins MG, Garratt A, Birchmeier C, Bennett DLH. Axonally derived Neuregulin-1 is required for remyelination and regeneration following nerve injury in adulthood. J Neurosci 2011; 31:3225-33.

Técnicas y modelos

Modelos animales de dolor neuropático e inflamatorio
Modelos animales de lesión de nervio periférico y médula espinal
Inyección intramedular
Evaluación funcional de dolor y regeneración: tests conductuales, electrofisiología.
Inmunofluorescencia. Histología convencional.
qPCR

Organización de Seminarios y Eventos

Convenios con Empresas Privadas o Laboratorios

Objetivos para los próximos años

Para más información, no dude en contactarnos: RGIA-info