Campos-Torres, Antonio


Universidad o Centro de Investigación: National University of Ireland Maynooth  

Departamento, unidad o laboratorio: Institute of Immunology  

Dirección postal: Department of Biology
National University of Ireland Maynooth
http://immunology.nuim.ie/Dr.AntonioCampos-Torres.shtml  

Código postal: Co. Kildare  

País: Irlanda  

Teléfonos de contacto:  

+(353-1) 708 6125  

Fax: (353-1)  

Correos electrónicos de contacto:  

  Antonio.Campos-Torres@ucd.ie 

 Antonio.CamposTorres@nuim.ie 


Linea(s) de investigación

Dr. Antonio Campos-Torres, Research Interests:

Glial Cells Biology in Immunity and Neuronal Plasticity

My research interests have been on understanding the cellular and molecular mechanisms underlying the function of Glial cells (Astrocytes and Microglia) and their interactions with neurons and peripheral immune cells (i.e. Macrophages, T cells). These interests are focused on the Central Nervous System (CNS) based on strong evidence for the role that Glial cells play in orchestrating the CNS Innate Immune response during neuroinflammatory and neurodegenerative conditions.

The CNS Innate Immune response is characterized by the activation of Neurons and Glial cells and by the engagement of the two arms of Innate Immunity (Complement System and Toll-like receptors, TLRs) resulting in rapid production of inflammatory cytokines and chemokines via activation of intracellular signalling pathways, i.e., NF-κB, IRFs. Within this context Glial cells play a fundamental role in the preservation of host tissue integrity/homeostasis in the CNS immune response to pathogens and to endogenous "danger" signals. Glial cells have been also implicated in the onset and progression of neuropathological mechanisms in multiple sclerosis, Alzheimer’s disease, stroke, HIV encephalitis, brain/spinal cord trauma and central/peripheral nerve injury.

My above research interests are integrated and approached through a combination of In Vitro (molecular biology, proteomics, cell culture, gene transfection, immunocytochemical techniques and molecular imaging) and In Vivo (development of animal models of neuroinflammation/neurodegeneration) techniques and through the expansion of my scientific findings into translational studies.

Key words: Complement System, Toll-like Receptors, Innate Immunity, Glial Activation, Microglia, Astrocytes, Neuroinflammation, Neurodegeneration, Nerve Regeneration, Post-lesional CNS Plasticity, Animal models of disease.

Miembros del grupo

Nombre: Marion Nidetzki  

Nombre: Julia Hee  

Nombre: Juliane Roper  

Publicaciones más relevantes

Técnicas y modelos

Projects :

Cellular, Molecular and Metabolic Mechanisms of Microglia and Astrocytes function

Role of TLRs signalling in the CNS

Complement Cascade activation and CNS Innate Immune Reponse

Peripheral and Central Nervous System Regeneration

Animal models: LPS endotoxemia, Sepsis CLIP Model, Experimental Autoimmune Encephalomyelitis (EAE), Peripheral Nerve Injury, Spinal Cord Injury,Vestibular compensation

Organización de Seminarios y Eventos

- International Neuroimmunology Symposium, University College Dublin,
13th-14th March 2008

- Neurinfnet Meeting, COST Action BM0603, Inflammation in Brain Disease,
University College Dublin, 3rd June 2011

Convenios con Empresas Privadas o Laboratorios

Collaborators:

Dr Jana Haase, UCD School of Biomolecular and Biomedical Science, Dublin, Ireland

Dr. Gethin McBean, UCD School of Biomolecular and Biomedical Science, Dublin, Ireland

Professor Roland Pochet, Universite Libre de Bruxelles, Belgium

Objetivos para los próximos años

Para más información, no dude en contactarnos: RGIA-info