Gottfried, Carmem


Universidad o Centro de Investigación: Universidade Federal do Rio Grande do Sul- UFRGS  

Departamento, unidad o laboratorio: Bioquímica  

Dirección postal: cgottfried@ufrgs.br  

Código postal: 90035003  

País: Brasil  

Teléfonos de contacto:  

330805565  

Fax: 330805534  

Correos electrónicos de contacto:  

  cgottfried@ufrgs.br  


Linea(s) de investigación

1. Autism spectrum
2. Natural drugs and neuroprotection
3. Peripheral receptors and neuroimmunomodulation

Miembros del grupo

Nombre: Tamara Vaccaro  

Nombre: Roberta Silvestrin  

Nombre: Victorio Bambini-Junior  

Nombre: Renata Abib  

Nombre: Laura Stertz  

Publicaciones más relevantes

Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase ACTIVITY in wistar rats.
Ribeiro LC, Quincozes-Santos A, Leite MC, Abib RT, Kleinkauf-Rocha J, Biasibetti R, Rotta LN, Wofchuk ST, Perry ML, Gonçalves CA, Gottfried C.
Neurosci Res. 2009, 64:330-4


Gap junction inhibitors modulate S100B secretion in astrocyte cultures and acute hippocampal slices.
Leite MC, Galland F, de Souza DF, Guerra MC, Bobermin L, Biasibetti R, Gottfried C, Gonçalves CA.
J Neurosci Res. 2009, [Epub ahead of print]


S100B Secretion in Acute Brain Slices: Modulation by Extracellular Levels of Ca(2 ) and K ( ).
Nardin P, Tortorelli L, Quincozes-Santos A, de Almeida LM, Leite MC, Thomazi AP, Gottfried C, Wofchuk ST, Donato R, Gonçalves CA.
Neurochem Res. 2009 [Epub ahead of print]


Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat.
Vicente E, Degerone D, Bohn L, Scornavaca F, Pimentel A, Leite MC, Swarowsky A, Rodrigues L, Nardin P, de Almeida LM, Gottfried C, Souza DO, Netto CA, Gonçalves CA.
Brain Res. 2009, 1251:204-12.


S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway.
de Souza DF, Leite MC, Quincozes-Santos A, Nardin P, Tortorelli LS, Rigo MM, Gottfried C, Leal RB, Gonçalves CA.
J Neuroimmunol. 2009, 206:52-7.


Atypical neuroleptic risperidone modulates glial functions in C6 astroglial cells.
Quincozes-Santos A, Bobermin LD, Kleinkauf-Rocha J, Souza DO, Riesgo R, Gonçalves CA, Gottfried C.
Prog Neuropsychopharmacol Biol Psychiatry. 2009, 33:11-5


Resveratrol protects against oxidative injury induced by H2O2 in acute hippocampal slice preparations from Wistar rats.
de Almeida LM, Leite MC, Thomazi AP, Battu C, Nardin P, Tortorelli LS, Zanotto C, Posser T, Wofchuk ST, Leal RB, Gonçalves CA, Gottfried C.
Arch Biochem Biophys. 2008, 480:27-32.


Ketogenic diet-fed rats have increased fat mass and phosphoenolpyruvate carboxykinase activity.
Ribeiro LC, Chittó AL, Müller AP, Rocha JK, Castro da Silva M, Quincozes-Santos A, Nardin P, Rotta LN, Ziegler DR, Gonçalves CA, Da Silva RS, Perry ML, Gottfried C.
Mol Nutr Food Res. 2008, 52:1365-71.


Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin.
Tramontina AC, Tramontina F, Bobermin LD, Zanotto C, Souza DF, Leite MC, Nardin P, Gottfried C, Gonçalves CA.
Prog Neuropsychopharmacol Biol Psychiatry. 2008, 32:1580-3.


Effects of intensive glucose lowering in type 2 diabetes.
Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT.
N Engl J Med. 2008, 358:2545-59.


Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells.
Souza IC, Martins LA, Coelho BP, Grivicich I, Guaragna RM, Gottfried C, Borojevic R, Guma FC.
Mol Cell Biochem. 2008, 315:1-7.


Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells.
Quincozes-Santos A, Abib RT, Leite MC, Bobermin D, Bambini-Junior V, Gonçalves CA, Riesgo R, Gottfried C.
Mol Cell Biochem. 2008, 314:59-63.


Glial alterations in the hippocampus of rats submitted to ibotenic-induced lesion of the nucleus basalis magnocellularis.
Swarowsky A, Rodrigues L, Biasibetti R, Leite MC, de Oliveira LF, de Almeida LM, Gottfried C, Quillfeldt JA, Achaval M, Gonçalves CA.
Behav Brain Res. 2008, 190:206-11.


A simple, sensitive and widely applicable ELISA for S100B: Methodological features of the measurement of this glial protein.
Leite MC, Galland F, Brolese G, Guerra MC, Bortolotto JW, Freitas R, Almeida LM, Gottfried C, Gonçalves CA.
J Neurosci Methods. 2008, 169:93-9.


Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage.
Abib RT, Quincozes-Santos A, Nardin P, Wofchuk ST, Perry ML, Gonçalves CA, Gottfried C.
Mol Cell Biochem. 2008, 310:153-8.


Profile of glutamate uptake and cellular viability in hippocampal slices exposed to oxygen and glucose deprivation: developmental aspects and protection by guanosine.
Thomazi AP, Boff B, Pires TD, Godinho G, Battú CE, Gottfried C, Souza DO, Salbego C, Wofchuk ST.
Brain Res. 2008, 1188:233-40.

Developmental changes in content of glial marker proteins in rats exposed to protein malnutrition.
Feoli AM, Leite MC, Tramontina AC, Tramontina F, Posser T, Rodrigues L, Swarowsky A, Quincozes-Santos A, Leal RB, Gottfried C, Perry ML, Gonçalves CA.
Brain Res. 2008, 1187:33-41.



S100B levels in the cerebrospinal fluid of rats are sex and anaesthetic dependent.
Vicente E, Tramontina F, Leite MC, Nardin P, Silva M, Karkow AR, Adolf R, Lucion AB, Netto CA, Gottfried C, Gonçalves CA.
Clin Exp Pharmacol Physiol. 2007, 34:1126-30.




Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte cultures.
Vieira de Almeida LM, Piñeiro CC, Leite MC, Brolese G, Leal RB, Gottfried C, Gonçalves CA.
Neurochem Res. 2008, 33:8-15.


Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures.
de Almeida LM, Piñeiro CC, Leite MC, Brolese G, Tramontina F, Feoli AM, Gottfried C, Gonçalves CA.
Cell Mol Neurobiol. 2007, 27:661-8.

Resveratrol attenuates oxidative-induced DNA damage in C6 Glioma cells.
Quincozes-Santos A, Andreazza AC, Nardin P, Funchal C, Gonçalves CA, Gottfried C.
Neurotoxicology. 2007, 28:886-91.

S100B content and secretion decrease in astrocytes cultured in high-glucose medium.
Nardin P, Tramontina F, Leite MC, Tramontina AC, Quincozes-Santos A, de Almeida LM, Battastini AM, Gottfried C, Gonçalves CA.
Neurochem Int. 2007, 50:774-82


Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.
Zamoner A, Funchal C, Jacques-Silva MC, Gottfried C, Barreto Silva FR, Pessoa-Pureur R.
Cell Mol Neurobiol. 2007, 27:845-65.


Branched-chain amino acids accumulating in maple syrup urine disease induce morphological alterations in C6 glioma cells probably through reactive species.
de Lima Pelaez P, Funchal C, Loureiro SO, Heimfarth L, Zamoner A, Gottfried C, Latini A, Wajner M, Pessoa-Pureur R.
Int J Dev Neurosci. 2007, 25:181-9.


Immunoassay for glial fibrillary acidic protein: antigen recognition is affected by its phosphorylation state.
Tramontina F, Leite MC, Cereser K, de Souza DF, Tramontina AC, Nardin P, Andreazza AC, Gottfried C, Kapczinski F, Gonçalves CA.
J Neurosci Methods. 2007, 162:282-6.


Can electrons travel through actin microfilaments and generate oxidative stress in retinol treated Sertoli cell?
de Oliveira RB, de Bittencourt Pasquali MA, Filho AZ, Dalmolin RJ, Gelain DP, Gottfried C, Rodrigues JL, Klamt F, Moreira JC.
Mol Cell Biochem. 2007, 301:33-45.



Serum S100B and antioxidant enzymes in bipolar patients.
Andreazza AC, Cassini C, Rosa AR, Leite MC, de Almeida LM, Nardin P, Cunha AB, Ceresér KM, Santin A, Gottfried C, Salvador M, Kapczinski F, Gonçalves CA.
J Psychiatr Res. 2007, 41:523-9.

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