von Bernhardi Montgomery, Rommy

Universidad o Centro de Investigación: Pontificia Universidad católica de Chile  

Departamento, unidad o laboratorio: Departamento Neurología  

Dirección postal: Laboratorio Neurociencia
Departamento Neurología
Facultad de Medicina
Pontificia Universidad Católica de Chile
Marcoleta 391, Santiago, Chile  

Código postal: 8330024  

País: Chile  

Teléfonos de contacto:  

56 2 354 6936  

Fax: 56 2 632 1924  

Correos electrónicos de contacto:  



Linea(s) de investigación

Our research is focused on the role of glial cell activation on
neurodegeneration. We are especially interested in the effect of
pathophysiological conditions, such as aging and inflammatory stressors,
on glial cell function and regulation. We also study immunomodulation
(stem cells and glia/neuron), the biological mechanisms involved in
immunotherapy, and the participation of glia in damage propagation
induced by trauma.
Our studies on cell culture, organotypic slices and transgenic animal
models, involve a wide range of methodological approaches including biochemistry, morphology, immuno-histochemistry, cell
biology, molecular biology, cell physiology, electrophysiology and
neurobehavioral evaluation.
Evidence from our research support our hypothesis that glial cell
dysfunction is an early event in the pathogenesis of Alzheimer’s disease
(von Bernhardi, 2007). Currently, we are pursuing 5 different problems:
i)cytokines and radical molecules, ii) effect of hypoxia on glia reactivity,
iii) involvement of scavenger receptors on inflammatory activation of glial
cells, iv) effect of aging on neuroinflammation, v) cytokines on
age-dependent changes of neuronal function.
Our ultimate goal is to understand the interactions among neurons and glia
involved in aging and neuroinflammation. Although our work is mostly basic
research, it has implications for understanding the fundamental mechanisms
relevant to neuroimmunomodulation, aging-dependent changes and human
neurological disorders associated to dementia.

Miembros del grupo

Nombre: Juan Tichauer E-mail: jtichauer@gmail.com  

Nombre: Bernardita Soler E-mail: pitusoler@gmail.com  

Nombre: Gigliola Ramírez Rojas E-mail: gigliolaramirez@yahoo.es  

Nombre: Dagoberto Soto E-mail: dasoto@illinois.edu  

Nombre: Elizabeth Medina E-mail: e.medina.urzua@gmail.com  

Nombre: Paola Murgas E-mail: paolamurgas@gmail.com  

Nombre: Maximiliano Rovegno E-mail: maxrovegno@gmail.com  

Nombre: Betsi Flores E-mail: x.bexi.x@gmail.com  

Nombre: María Gonzales E-mail: negra105@gmail.com  

Nombre: Laura Eugenín E-mail: lau_euge@yahoo.com  

Publicaciones más relevantes

- Cancino GI, Perez de Arce, Castro PU, Toledo EM, von Bernhardi R,
Alvarez AR. (2010) c-Abl tyrosine kinase modulates tau pathology
and Cdk5 phosphorylation in an AD model transgenic mice.
Neurobiol Aging, Aug 22 2009. [Epub ahead of print] doi:10.1016/j.neurobiolaging.2009.07.007.
- von Bernhardi R, Tichauer J, Eugenín J. (2010) Aging-dependent changes
of microglial cells and their relevance for neurodegenerative disorders
J. Neurochem.112:1099-114. Epub 2009 Dec 10. doi: 10.1111/j.1471-4159.2009.06537.x
- von Bernhardi R. (2010) Immunotherapy in Alzheimer Disease: Where do we stand? Where should we go? J Alzheimer Dis. 19(2):405-21; Oct 8, 2009. doi:10.3233/JAD-2009-1248.
- Uribe-San.Martín R, Herrera-Molina R, Olavarría L, Ramírez G,
von Bernhardi R. (2009) Reduction of β-Amyloid -Induced Neurotoxicity
on Hippocampal Cell Cultures by Moderate Acidosis is mediated by TGFβ.
Neuroscience 158, 1338-1347. [Epub ahead of print]. doi:10.1016/j.neuroscience.2008.11.002.
- Eugenín J, Otárola M, Bravo E, Coddou C, Cerpa V, Reyes-Parada M,
Llona I, von Bernhardi R. (2008) Prenatal to early postnatal nicotine
exposure impairs central chemoreception and modifies breathing pattern
in mouse neonates: a probable link to sudden infant death syndrome.
J. Neurosci. 28(51):13907–13917.
- Ramírez G, Rey S, von Bernhardi R. (2008). Proinflammatory stimuli induce
microglial cell- mediated APP- and Aβ- neurotoxicity in hippocampal cultures.
J Alzheimer Dis 15(1):45-59.
- von Bernhardi R. (2007). Glial cell dysregulation: a new perspective
on Alzheimer disease. Neurotoxicity Res. 12(4): 215-232.
- Tichauer J, Saud K, von Bernhardi R. (2007). Modulation by astrocytes
of microglial cell-mediated neuroinflammation: Effect on the activation
of microglial signaling pathways. Neuroimmunomodulation. 14: 168-174.
- von Bernhardi R, Ramírez G, Toro R, Eugenín J. (2007) Pro-inflammatory
conditions promote neuronal damage mediated by Amyloid Precursor Protein
and decrease its phagocytosis and degradation by microglial cells in culture.
Neurobiol Disease. 26: 153-164. (2006 Dec 16; [Epub ahead of print]).
- Eugenín J, von Bernhardi R, Muller KJ, Llona I. (2006). Development
and pH sensitivity of the respiratory rhythm of fetal mice in vitro.
Neuroscience 141(1): 223-231 (May 2005 Epub ahead of print).
- Saud K, Herrera-Molina R, von Bernhardi R. (2005) Pro- and anti-inflammatory
cytokines regulate the ERK pathway: implication of the timing for the
activation of microglial cells. Neurotoxicity Research. 8 (3,4): 277-287.
- Alarcón R, Fuenzalida C, Santibañez M, von Bernhardi R. (2005) Expression
of Scavenger Receptors in glial cells: Comparing the adhesion of astrocytes
and microglia from neonatal rats to surface-bound β-amyloid.
J. Biol. Chem. 280: 30406-30415.
- Herrera-Molina R, von Bernhardi R. (2005) Transforming growth factor-β1
produced by hippocampal cells modulates glial reactivity in culture.
Neurobiol Disease 19: 229-236.
- Ramírez G, Toro R, Döbeli H, von Bernhardi R. (2005) Protection
of rat primary hippocampal cultures from Aß cytotoxicity by pro-inflammatory
molecules is mediated by astrocytes. Neurobiol Disease 19: 243-254.
- von Bernhardi R, Alarcón R, Mezzano D, Fuentes P, Inestrosa NC. (2005)
Blood cells cholinesterase activity in early stage Alzheimer’s disease and
other dementias. Dementia and geriatric cognitive disorders 19: 204-212.

Técnicas y modelos

transgenic animal models: APP/PS1, MaFIA, SRA-KO
primary cells and cell lines culture
organotypic slice cultures
biochemistry, morphology, immuno-histochemistry, cell
biology, molecular biology, cell physiology, electrophysiology and
neurobehavioral evaluation.

Organización de Seminarios y Eventos

Convenios con Empresas Privadas o Laboratorios

Objetivos para los próximos años

Para más información, no dude en contactarnos: RGIA-info