Gonzálo Ruiz, Alicia


Universidad o Centro de Investigación: Instituto de Neurociencias de Castilla y León.Universidad de Valladolid  

Departamento, unidad o laboratorio: Laboratorio de Neuroanatomía  

Dirección postal: Carretera de Madrid s/n. Campus "Duques de Soria"  

Código postal: 42004  

País: España  

Teléfonos de contacto:  

+34 975 12 9184  

34 975 636 255555  

Correos electrónicos de contacto:  

  agruiz@ah.uva.es 


Linea(s) de investigación

Analizar y valorar, en la rata como modelo animal de neurodegeneración, posibles mecanismos inflamatorios involucrados en la toxicidad del péptido Aβ. Así como mecanismos por los que el calcio participa en la activación de astrocitos en fases tempranas (24h – 2 semanas) de la toxicidad inducida por el péptido Aβ1-42.

Miembros del grupo

Nombre: José Miguel Sanz Anquela E-mail: jmsanzquela@hotmail.es  

Nombre: Juan Arévalo Serrano E-mail: j.arevalos@personas.net  

Nombre: Isabel Carrero Ayuso E-mail: icarreroa@bio.uva.es  

Nombre: Mª Pilar Gonzalo Vicente E-mail: pgonzalo@pat.ubva.es  

Publicaciones más relevantes

A. Gonzalo-Ruiz, J. L. Pérez, J.M. Sanz, C. Geula, J. Arévalo.Effects of lipids and aging on the neurotoxicity and neuronal loss caused by intracerebral injections of the amyloid- peptide in the rat.
Experimental Neurology 58: 136-158 (2006)

AUTORES: A. Gonzalo- Ruiz, J. Arévalo Serrano.Interaction between β-amyloid protein and the α7 nicotinic acetylcholine receptor in cholinergic, GABAergic and calcium-binding proteins-containing neurons of the septum-diagonal band complex of the rat
Eur. J. of Anatomy 10 (3): 164-179 (2006).

J. L. Pérez, I. González, J. Arévalo, A. Gonzalo-Ruiz. Interaction between extracellular deposit of Beta-amyloid protein, gliosis and alterations in selective proteins in the brain of the rat
J. Devel. Neuroscience 24: 210-211 (2006)

I. González, J.Arévalo-Serrano, J.L. Pérez, J.M. Sanz-Anquela, A. Gonzalo-Ruiz,
Effects of β-amyloid protein on muscarinic acetylcholine receptors in the septum-diagonal band of the rat”.
Acta Neuropathol 113: 637-651 (2007)

A. Gonzalo-Ruiz, J. Arévalo-Serrano, F. Olucha, J.M. Sanz-Anquela (2007)
Effects of β-Amyloid Protein on α7 Nicotinic Acetylcholine Receptor in Hippocampus of the Rat: Relationship with GABAergic and Calcium Binding Proteins Perikarya
In Neurotoxicity Syndromes. Linda R. Wester (ed.). Nova Science Publishers, Inc. Chapter 5. ISBN 978-1-60021-797-5


A. Gonzalo-Ruiz. Deposit of β-amyloid induced gliosis and alterations in synaptic proteins in the cerebral cortex of the rat.
PUBLICADO: In Alzheimer’s disease: NEW ADVANCES. Iqbal k, Windbland B, Avila J (eds), Medimond International, Italy, pp 413-419.
ISBN 978-88-7587-322-6.

J. Arévalo-Serrano, J. M. Sanz-Anquela, A. Gonzalo-Ruiz.
Βeta-amyloid peptide-induced modifications in α7 nicotinic acetylcholine receptor immunoreactivity in the hippocampus of the rat.
Brain Res. Bulletin Vol., 75 (5): 134 – 143, 2008


I. González, J. Arévalo-Serrano, J. L. Pérez, P. Gonzalo, A. Gonzalo-Ruiz.
Effects of Βeta-amyloid peptide on the density of M2 muscarinic acetylcholine receptor immunoreactivity in the hippocampus of the rat.
Neurophatology and Applied Neurobiology 34: 506-522, 2008

A. Gonzalo-Ruiz, JL. Pérez, P. Gonzalo, M. Rodríguez, JM. Sanz-Anquela, J. Arévalo-Serrano, I. Carrero. Beta-amyloid (Aβ) peptide induces increase in the expression of two cycloxygensae-2 (COX-2) protein bands in the rat brain.
J. of Chemistry Vol. 110, Suppl. 1, pp. 39 (2009)

A. Gonzalo-Ruiz, P. Gonzalo, J.L. Pérez. Oligomers of β-amyloid (Aβ) peptide induce co-localization of Aβ and TAU proteins associated with calpain activity.
J. of Chemistry Vol 110 Suppl. 2 (2009)

A. Gonzalo-Ruiz, I. Carrero, M. Rodríguez, J.M. Sanz-Anquela, J. L. Pérez. Beta-amyloid (Aβ) peptide induces calpain activity in reactive astrocytes through activation of NF-kB and NFAT in the rat brain.
Glia Vol.57, Suppl.13, pp.103 (2009)

P. Shah, N. Lal, E. Leung, D. Traul, A. Gonzalo-Ruiz, C. Geula. Neuronal and axonal loss are selectively linked to fibrillar Amyloid-beta within plaques of the Aged Primate Cerebral Cortex
American Journal of Pathology 177: 325-333 (2010)


J. L. Pérez, I. Carrero, P. Gonzalo, J. Arévalo-Serrano, J. M. Sanz- Anquela, J. Ortega, M. Rodriguez, A. Gonzalo-Ruiz. Soluble oligomeric forms of Beta-amyloid (Aβ) peptide stimulate Aβ production via astrogliosis in the rat brain.
Experimental Neurology 223: 410-421 (2010)

A. Gonzalo-Ruiz, P. Gonzalo, J.M. Sanz-Anquela, J. Arévalo-Serrano, I. Carrero.
Oligomers of β-amyloid (Aβ) peptide induce upregulation of cyclooxygenase-2 (COX-2) and of inducible oxide nitric (iNOS) in astrocytes via an interaction with nuclear factor KappaB proteins.
Neurodegenerative Diseases Journal 8 (2011)


A. Gonzalo-Ruiz, M. Delso, I. Carrero, MP. Gonzalo, JM. Sanz- Anquela, M. Rodriguez, J. Arévalo-Serrano.
A rat model of oligomeric forms of beta-amyloid (Aβ) peptide: neuronal loss, synaptic alterations, astrogliosis, and calcium-biding proteins activation in vivo.
Eur. J. of Anat. 15 (1): 25-60 (2011)



Técnicas y modelos

Organización de Seminarios y Eventos

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Objetivos para los próximos años

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