Bolanos, Juan P


Universidad o Centro de Investigación: Universidad de Salamanca  

Departamento, unidad o laboratorio: Departamento de Bioquímica y Biología  

Dirección postal: Edificio Departamental, Laboratorio 122,
Campus Miguel de Unamuno,
Plaza Doctores de la Reina, s/n,
Salamanca  

Código postal: 37007  

País: España  

Teléfonos de contacto:  

 

+34 92 32 945 26  

Fax: 34923294579  

Correos electrónicos de contacto:  

 jbolanos@usal.es  


Linea(s) de investigación

1. Molecular mechanisms involved in neuronal survival and neurodegeneration.
2. Regulation of neural energy metabolism.
3. Cell signalling by reactive oxygen and nitrogen species.

Miembros del grupo

Nombre: Monica Resch-Beusher E-mail: mresch@usal.es  

Nombre: Emilio Fernandez E-mail: emiliofs@usal.es  

Nombre: Daniel JImenez-Blasco E-mail: danijb@usal.es  

Nombre: Seila Fernandez-Fernandez E-mail: a90200@usal.es  

Nombre: Ruben Quintana-Cabrera E-mail: ruben310@usal.es  

Nombre: Patricia Rodriguez-Rodriguez E-mail: patry_2r@usal.es  

Publicaciones más relevantes

Herrero-Mendez A, Almeida A, Fernandez E, Maestre C, Moncada S and Bolanos JP.

The bioenergetic and antioxidant status of neurons is controlled by proteosomal degradation of a key glycolytic enzyme by APC/C-Cdh1.

Nat. Cell Biol. 11:747-752 (2009)

Minelli A, Conte C, Grottelli S, Bellezza I, Cacciatore I and Bolanos JP.

Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up regulation of antioxidant defence
.
J. Cellular Med. 13:1149-1161 (2009)

Bolaños JP and Heles SJ

Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications.

Front Neuroenergetics 2:1-5 (2010)

Bolaños JP, Almeida A and Moncada S.

Glycolysis - a bioenergetic or a survival pathway?

Trends Biochem. Sci.35:145-149 (2010)

Bolaños JP and Almeida A.

The pentose-phosphate pathway in neuronal survival against nitrosative stress.

IUBMB Life 62:14-18 (2010)

Bolaños JP, Moro MA, Lizasoain I, Almeida A.

Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.

Adv Drug Deliv Rev.61:1299-1315 (2009)

Bolanos JP, Delgado-Esteban M, Herrero-Mendez A, Fernandez-Fernandez S and Almeida A.

Regulation of glycolysis and pentose-phosphate pathway by nitric oxide: impact on neuronal survival.

Biochim. Biophys. Acta 1777:789-793 (2008)

Bolanos JP, Herrero-Mendez A, Fernandez-Fernandez S and Almeida A.

Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide.

Biochem. Soc. Trans 35:1224-1227 (2007)

Moncada S and Bolanos JP

Nitric oxide, cell bioenergetics and neurodegeneration.

J. Neurochem. 97:1676-1689 (2006).

Bolanos JP and Almeida A.

Nitric oxide in glial cells.

Antiox. Redox Signaling 8:955-965 (2006).

Minelli A, Conte C, Grottelli S, Bellezza I, Cacciatore I and Bolanos JP.

Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up regulation of antioxidant defence
.
J. Cellular Med. 13:1149-1161 (2009)

Maestre C, Delgado-Esteban M, Gomez-Sanchez JC, Bolanos JP, Almeida A.

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity
.
EMBO J. 27:2736-2745 (2008)

Cuende J, Moreno S, Bolanos JP and Almeida A.

Retinoic acid down regulates Rae1 leading to APC-Cdh1 activation and neuroblastoma SH-SY5Y differentiation
.
Oncogene 27:3339-3344 (2008)

Diaz-Hernandez JI, Moncada S, Bolanos JP and Almeida A.

Poly(ADP) ribose polymerase-1 protects neurons against apoptosis induced by oxidative stress
.
Cell Death Differ. 14:1211-1221 (2007)

Delgado-Esteban M, Martin-Zanca D, Andres-Martin L, Almeida A and Bolanos JP.

Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway.

J. Neurochem. 102:194-205 (2007)

Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, Fernandez E and Bolanos JP.

Knockdown of glutamate-cysteine ligase by small hairpin RNA (shRNA) reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons.

J. Biol. Chem. 280:38992-9001 (2005).

Almeida A, Bolanos JP and Moreno S.

Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.

J. Neurosci. 25, 8115-8121 (2005).

Garcia O, Almeida A, Massieu L and Bolanos JP.

Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation.

J. Neurochem. 92: 183-190 (2005).

Cidad P, Almeida A and Bolanos JP.

Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase.

Biochem. J. 384: 629-636 (2004).

Almeida A, Moncada S and Bolanos JP.

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

Nat. Cell Biol. 6:45-51 (2004).

Garcia-Nogales P, Almeida A and Bolanos JP.

Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection.

J. Biol. Chem. 278:864-874 (2003).

Técnicas y modelos

Neural cells primary culture.
Molecular Biology.
Genetically-modified mice as neurodegenerative diseases models.

Organización de Seminarios y Eventos

Convenios con Empresas Privadas o Laboratorios

Objetivos para los próximos años

Para más información, no dude en contactarnos: RGIA-info